Haku
Viitteet 11-19 / 19
The Dynamic Structural Effects of Activating ERBB Kinase Somatic Mutations
(Åbo Akademi University, 2021-10-15)
The ERBB family of receptor tyrosine kinases, epidermal growth factor receptor (EGFR, ERBB1), ERBB2, ERBB3 and ERBB4, are transmembrane signaling proteins that regulate cellular processes such as cell survival, mobility, ...
Membrane lipid frustration : Contribution of ceramide and its effects on lateral segregation
(Åbo Akademi University, 2021-06-17)
Ceramides are both sphingolipid precursor molecules and breakdown products with effects on membranes that are of interest both from biophysical and physiological points of view. When present in a membrane, ceramide induces ...
Regulation of Host-Microbe Interactions and Inflammatory Signalling in Drosophila melanogaster
(Åbo Akademi University, 2021-12-10)
In order to eliminate harmful pathogens, while allowing beneficial microbes to persist, inflammatory signalling in the intestine needs to be carefully regulated. Overactive immune signalling can lead to chronic inflammation ...
Virulence and survival mechanisms in Borrelia and Klebsiella infections – a structural bioinformatics perspective
(Åbo Akademi University, 2021-06-23)
Bacteria use a wide variety of mechanisms to establish an infection in their host and to compete with other microorganisms for space and nutrients. These virulence and survival mechanisms mainly rely on the functions of ...
Spatial control of angiogenesis by engineered patterns of Notch ligands
(Åbo Akademi - Åbo Akademi University, 2022-10-04)
Spatial control of angiogenesis by engineered patterns of Notch
In tissue engineering and regenerative medicine, proper vascularization of engineered tissues is imperative, as diffusion of nutrients, oxygen and waste is ...
The Role of Exosomal Vimentin in Mediating Wound Healing
(Åbo Akademi - Åbo Akademi University, 2022-11-16)
Despite great advances in tissue engineering and regenerative medicine,impaired wound healing is still a challenging clinical problem. Accumulating evidence demonstrates the ability of extracellular vesicles and specifically, ...
Met1-ubiquitination determines inflammatory signalling in Drosophila melanogaster
(Åbo Akademi - Åbo Akademi University, 2022-06-15)
The innate immune response is an immediate immune response facilitated by the host to combat pathogen invasion and other harmful stimuli, such as damaged cells and environmental irritants. It is activated when pattern-recognising ...
Regulation of Inflammatory Signalling by Caspases and M1-linked Ubiquitin Chains in Drosophila melanogaster
(Åbo Akademi - Åbo Akademi University, 2023-11-30)
The NF-κB family of transcription factors are master regulators of innate immune responses and their dysregulation can lead to chronic inflammation and cause diseases like inflammatory bowel disease and cancer. To treat ...
Bioimage Analysis for Life Scientists : Tools for Live Cell Imaging
(Åbo Akademi - Åbo Akademi University, 2024-04-26)
Live imaging is essential in visualizing biological processes such as normal tissue development, wound healing, and cancer — processes too small for the bare human eye to observe. Optical microscopy has enabled the ...