1182 Biokemia, solu- ja molekyylibiologia
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Regulation of Inflammatory Signalling by Caspases and M1-linked Ubiquitin Chains in Drosophila melanogaster
(Åbo Akademi - Åbo Akademi University, 30.11.2023)The NF-κB family of transcription factors are master regulators of innate immune responses and their dysregulation can lead to chronic inflammation and cause diseases like inflammatory bowel disease and cancer. To treat ... -
HSF1 and HSF2 in Stress and EMT-Associated Transcriptional Networks
(Åbo Akademi - Åbo Akademi University, 15.09.2023)Protein-damaging stress frequently occurs during the lifetime of a cell. To survive these insults, cells rely on the action of proteins called transcription factors that adjust the expression of genes, such as chaperones, ... -
Regulation of Death Receptor Responses by Hyperthermia
(Åbo Akademi - Åbo Akademi University, 01.06.2007)Cells need a variety of responses to protect themselves against stresses caused by changes in the environment. Likewise, a complex apoptotic machinery is necessary for elimination of cells that are no longer needed in the ... -
Calcium Signaling in Cell Compartments - the Importance of Sphingosine Kinase 1 and ORP5/8
(Åbo Akademi - Åbo Akademi University, 21.06.2023)För att upprätthålla liv använder cellerna i en organism intrikata signaleringsräckor för regleringen av fysiologiska processer inom enskilda celler och mellan olika celler och vävnaderna som utgör en organism. Reglering ... -
Intertwining Cell Adhesion, Gene Expression, and Stress
(Åbo Akademi - Åbo Akademi University, 01.06.2023)Cells within an organism are constantly exposed to environmental insults that challenge the homeostasis of their proteome by causing protein misfolding. To survive these adverse situations, cells are equipped with a ... -
The Role of Vimentin in Tissue Repair and Cell Growth
(Åbo Akademi - Åbo Akademi University, 10.03.2023)Microfilaments, microtubules, and intermediate filaments serve as the cytoskeleton of the cell and form a complex network by interacting with cytoskeleton-associated proteins. The cytoskeleton provides a framework for the ... -
Specificity Determining Features at the Interface of Biomolecular Complexes as Regulators of Biological Functions
(Åbo Akademi - Åbo Akademi University, 13.01.2023)Amino acid residues at the biomolecular interface play essential roles in many biological and cellular processes; relevant to this thesis, protein-protein interactions regulate signaling pathways and enzymatic activity, ... -
The Role of Exosomal Vimentin in Mediating Wound Healing
(Åbo Akademi - Åbo Akademi University, 16.11.2022)Despite great advances in tissue engineering and regenerative medicine,impaired wound healing is still a challenging clinical problem. Accumulating evidence demonstrates the ability of extracellular vesicles and specifically, ... -
Spatial control of angiogenesis by engineered patterns of Notch ligands
(Åbo Akademi - Åbo Akademi University, 04.10.2022)Spatial control of angiogenesis by engineered patterns of Notch In tissue engineering and regenerative medicine, proper vascularization of engineered tissues is imperative, as diffusion of nutrients, oxygen and waste is ... -
Met1-ubiquitination determines inflammatory signalling in Drosophila melanogaster
(Åbo Akademi - Åbo Akademi University, 15.06.2022)The innate immune response is an immediate immune response facilitated by the host to combat pathogen invasion and other harmful stimuli, such as damaged cells and environmental irritants. It is activated when pattern-recognising ... -
Mechanisms of Nascent Transcription in Cell Stress
(Åbo Akademi - Åbo Akademi University, 13.05.2022)Cells are constantly exposed to various types of stress, such as proteotoxic stress, oxidative stress, and hypoxia. Survival under these circumstances requires genome-wide reprogramming of transcription involving both ... -
Regulation of Host-Microbe Interactions and Inflammatory Signalling in Drosophila melanogaster
(Åbo Akademi University, 10.12.2021)In order to eliminate harmful pathogens, while allowing beneficial microbes to persist, inflammatory signalling in the intestine needs to be carefully regulated. Overactive immune signalling can lead to chronic inflammation ... -
The Dynamic Structural Effects of Activating ERBB Kinase Somatic Mutations
(Åbo Akademi University, 15.10.2021)The ERBB family of receptor tyrosine kinases, epidermal growth factor receptor (EGFR, ERBB1), ERBB2, ERBB3 and ERBB4, are transmembrane signaling proteins that regulate cellular processes such as cell survival, mobility, ... -
Vimentin links hemodynamic forces and Notch signaling in vascular tissue remodeling
(Åbo Akademi University, 09.07.2021) -
Virulence and survival mechanisms in Borrelia and Klebsiella infections – a structural bioinformatics perspective
(Åbo Akademi University, 23.06.2021)Bacteria use a wide variety of mechanisms to establish an infection in their host and to compete with other microorganisms for space and nutrients. These virulence and survival mechanisms mainly rely on the functions of ... -
Molecular Basis of the Sticholysin-Membrane Interaction : On the Structure of the Pore and the Effects of Lipids
(Åbo Akademi University Universidad Complutense de Madrid, 18.06.2021)The usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/or defense against external entities. Some of the most specialized of ... -
Membrane lipid frustration : Contribution of ceramide and its effects on lateral segregation
(Åbo Akademi University, 17.06.2021)Ceramides are both sphingolipid precursor molecules and breakdown products with effects on membranes that are of interest both from biophysical and physiological points of view. When present in a membrane, ceramide induces ... -
Development of Novel Drugs Targeting Chaperones of Oncogenic K-Ras
(Åbo Akademi - Åbo Akademi University, 12.02.2021)KRAS mutations account globally for about one million deaths per year, but there is as yet no approved drug against KRAS. K-Ras proteins are organized into di-/oligomeric nanoscale signaling complexes, known as nanoclusters ... -
Cellular regulation of the Notch signaling pathway by Notch-interacting proteins
(Åbo Akademi University, 25.09.2020)The Notch signaling mechanism is a crucial regulator of stem cells during development and tissue regeneration. Transcriptional activation of Notch target genes requires cleavage of the Notch receptor in response to ligand ... -
Identification of Three Conserved Interaction Zones Around the Catalytic Machinery of alpha/beta- Hydrolase Fold Enzymes
(Åbo Akademi - Åbo Akademi University, 06.03.2020)The alpha/beta-Hydrolases (ABH) comprise one of the largest structural families of proteins, found in all organisms. Although they share low sequence similarity, the ABH fold enzymes maintain a common catalytic domain, the ...
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