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    • Qualitative Methods for Modeling Biochemical Systems and Datasets : The Logicome and the Reaction Systems Approaches 

      Panchal, Charmi
      TUCS Dissertations : 229 (Turku Centre for Computer Science (TUCS), 12.02.2018)
      In our everyday life we use a number of complex systems that consist of many closely interconnected components. None of the individual components possess a property of the whole system but when they come together they give ...

    • Quantitative refinement of reaction-based biomodels 

      Iancu, Bogdan
      TUCS Dissertations : 199 (Turku Centre for Computer Science (TUCS), 25.06.2015)
      In the field of molecular biology, scientists adopted for decades a reductionist perspective in their inquiries, being predominantly concerned with the intricate mechanistic details of subcellular regulatory systems. ...

    • Recombination of Injected and Photogenerated Charge Carriers in Photovoltaic Blends and Devices 

      Sandén, Simon (Åbo Akademi - Åbo Akademi University, 16.03.2018)

    • Refinement of biomodels using Petri nets 

      Gratie, Diana-Elena
      TUCS Dissertations : 216 (Turku Centre for Computer Science (TUCS), 20.10.2016)
      Systems Biology is the multidisciplinary field concerned with the research of large, complex biological systems from a holistic perspective. The end goal is to understand how such systems function as a whole rather than ...

    • Regulation of cell fate by c-FLIP phosphorylation 

      Asaoka, Tomoko (Åbo Akademi - Åbo Akademi University, 13.12.2013)
      Programmed cell death is an important physiological cellular process that maintains homeostasis and protects multicellular organisms from diseases. Apoptosis is the principal mode of cell death, which eliminates unwanted ...

    • Regulation of cellular stress proteins in physiology and disease 

      Joutsen, Jenny (Åbo Akademi - Åbo Akademi University, 18.05.2018)
      All cells in a human body are constantly exposed to environmental fluctuations to which the cells must respond. Most of the cellular responses are mediated by proteins that are specifically regulated according to the ...

    • Regulation of Death Receptor Responses by Hyperthermia 

      Meinander, Annika (Åbo Akademi - Åbo Akademi University, 01.06.2007)
      Cells need a variety of responses to protect themselves against stresses caused by changes in the environment. Likewise, a complex apoptotic machinery is necessary for elimination of cells that are no longer needed in the ...

    • Regulation of Host-Microbe Interactions and Inflammatory Signalling in Drosophila melanogaster 

      Kietz, Christa (Åbo Akademi University, 10.12.2021)
      In order to eliminate harmful pathogens, while allowing beneficial microbes to persist, inflammatory signalling in the intestine needs to be carefully regulated. Overactive immune signalling can lead to chronic inflammation ...

    • Regulation of HSF2 and its function in mitosis 

      Elsing, Alexandra (Åbo Akademi - Åbo Akademi University, 26.09.2014)
      The cell is continuously subjected to various forms of external and intrinsic proteindamaging stresses, including hyperthermia, pathophysiological states, as well as cell differentiation and proliferation. Proteindamaging ...

    • Regulation of Inflammatory Signalling by Caspases and M1-linked Ubiquitin Chains in Drosophila melanogaster 

      Mohan, Aravind Kumar (Åbo Akademi - Åbo Akademi University, 30.11.2023)
      The NF-κB family of transcription factors are master regulators of innate immune responses and their dysregulation can lead to chronic inflammation and cause diseases like inflammatory bowel disease and cancer. To treat ...

    • Regulation of Notch Signaling by Intracellular Trafficking 

      Antfolk, Daniel (Åbo Akademi - Åbo Akademi University, 21.02.2020)
      The Notch signaling pathway is one of the essential mediators of cell-cell communication during development of multicellular organisms. Notch signaling is based on receptors and ligands that interact between neighboring ...

    • Removal of cyanobacterial toxins by strains of probiotic bacteria 

      Nybom, Sonja (Åbo Akademi - Åbo Akademi University, 21.12.2011)

    • Reusable formal architectures for networked systems 

      Kamali, Maryam
      TUCS Dissertations : 162 (Turku Centre for Computer Science (TUCS), 13.09.2013)
      Today's networked systems are becoming increasingly complex and diverse. The current simulation and runtime verification techniques do not provide support for developing such systems efficiently; moreover, the reliability ...

    • Rigorous development of safety-critical systems 

      Prokhorova, Yuliya
      TUCS Dissertations : 193 (Turku Centre for Computer Science (TUCS), 05.03.2015)
      Nowadays, computer-based systems tend to become more complex and control increasingly critical functions affecting different areas of human activities. Failures of such systems might result in loss of human lives as well ...

    • Role and regulatory mechanisms of heat shock factor 2 

      Björk, Johanna (Åbo Akademi - Åbo Akademi University, 04.11.2011)
      Protein homeostasis is essential for cells to prosper and survive. Various forms of stress, such as elevated temperatures, oxidative stress, heavy metals or bacterial infections cause protein damage, which might lead to ...

    • Role of the canonical transient receptor potential channel 2 (TRPC2) in thyroid cell function 

      Sukumaran, Pramod (Åbo Akademi - Åbo Akademi University, 08.02.2013)
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    • Scalable algorithms for height field illumination 

      Timonen, Ville
      TUCS Dissertations : 173 (Turku Centre for Computer Science (TUCS), 11.04.2014)
      Global illumination algorithms are at the center of realistic image synthesis and account for non-trivial light transport and occlusion within scenes, such as indirect illumination, ambient occlusion, and environment ...

    • Scalable Multicore Computing Using Dataflow and Task‐based Models 

      Georgakarakos, Georgios (Åbo Akademi University, 26.11.2021)
      Most of modern digital electronic devices and systems rely nowadays on multicore processors, in order to deliver a growing list of added‐value features and services. In this way multicore architectures have been able to ...

    • Scaling up stepwise feature introduction to construction of large software systems 

      Olszewski, Mikołaj
      TUCS Dissertations : 161 (Turku Centre for Computer Science (TUCS), 22.08.2013)
      Developing software is a difficult and error-prone activity. Furthermore, the complexity of modern computer applications is significant. Hence,an organised approach to software construction is crucial. Stepwise Feature ...

    • Scheduling dynamic dataflow graphs with model checking 

      Ersfolk, Johan
      TUCS Dissertations : 181 (Turku Centre for Computer Science (TUCS), 15.08.2014)
      With the shift towards many-core computer architectures, dataflow programming has been proposed as one potential solution for producing software that scales to a varying number of processor cores. Programming for parallel ...