Effect of breast cancer, doxorubicin chemotherapy and exercise on heart vascularization and cardiomyofibers
Latifi, Shiva (2023)
Latifi, Shiva
2023
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi-fe2023051143490
https://urn.fi/URN:NBN:fi-fe2023051143490
Tiivistelmä
Breast cancer is a prevalent cancer in women worldwide, and Doxorubicin (DOX) is an effective therapy for breast cancer patients that has improved survival rates. However, DOX and other anthracyclines can cause acute and chronic cardiotoxicity, known as anthracycline-induced cardiotoxicity (AIC), leading to heart failure. Therefore, there is a need to find ways to prevent or treat DOX-induced heart damage.
This thesis aimed to investigate the effects of breast cancer, DOX chemotherapy on heart vascularization and cardiomyofibers and the impact of exercise in mice. The study analyzed six test groups, including both trained and untrained mice with or without breast cancer and DOX treatment, using two different staining techniques on paraffin sections. The results showed that the breast cancer and DOX without exercise (BDC) group had a larger mean cell size, lower capillary density and relative heart mass (RHM) compared to the healthy control group. Exercise did not significantly increase final cardiac capillary density per cell, but a positive correlation with average daily running distance suggests some beneficial impact on capillarity. Additionally, exercise may visually increase the amount of glucose transporter 4 (GLUT4) in healthy animals, and also resulted in larger relative heart mass.
In conclusion, this thesis provides insights into the effects of breast cancer and DOX chemotherapy on heart health in mice. Exercise improves heart health in healthy mice, and non-pharmacological interventions may help prevent or treat DOX-induced heart damage. These findings are important for future studies on exercise's role in improving heart health.
This thesis aimed to investigate the effects of breast cancer, DOX chemotherapy on heart vascularization and cardiomyofibers and the impact of exercise in mice. The study analyzed six test groups, including both trained and untrained mice with or without breast cancer and DOX treatment, using two different staining techniques on paraffin sections. The results showed that the breast cancer and DOX without exercise (BDC) group had a larger mean cell size, lower capillary density and relative heart mass (RHM) compared to the healthy control group. Exercise did not significantly increase final cardiac capillary density per cell, but a positive correlation with average daily running distance suggests some beneficial impact on capillarity. Additionally, exercise may visually increase the amount of glucose transporter 4 (GLUT4) in healthy animals, and also resulted in larger relative heart mass.
In conclusion, this thesis provides insights into the effects of breast cancer and DOX chemotherapy on heart health in mice. Exercise improves heart health in healthy mice, and non-pharmacological interventions may help prevent or treat DOX-induced heart damage. These findings are important for future studies on exercise's role in improving heart health.