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c-Jun N-terminal Kinase (JNK) Regulation of Neuroplastic Changes in Brain Associated with Anxiety- and Depressive-like Behavior
(Åbo Akademi - Åbo Akademi University, 2019-05-17)
Anxiety disorders and clinical depression are leading causes of disability worldwide and affect more than 300 million people of all ages, more prominently women (World Health Organization, 2017). Comorbid depression and ...
The interplay of JNK and SCG10 during cortical development and in excitotoxic responses in brain
(Åbo Akademi - Åbo Akademi University, 2014-10-17)
Initially identified as stress activated protein kinases (SAPKs), the c-Jun Nterminal kinases (JNKs) are currently accepted as potent regulators of various physiologically important cellular events. Named after their ...
JNK regulation of neurogenesis, neuroplasticity and anxiety-related behaviors in mice
(Åbo Akademi - Åbo Akademi University, 2016-04-06)
I vår moderna värld har förekomsten av ångeststörningar drastiskt ökat, vilket påverkar välfärden i våra samhällen. Eftersom de molekylära mekanismerna bakom ångest är relativt okända, är möjligheterna till behandling ...
Novel tools to investigate and control JNK function in models of anxiety and depression
(Åbo Akademi - Åbo Akademi University, 2019-02-13)
JNK regulates dendrite and spine architecture in the central nervous system influencing spatial learning and motor tasks
(Åbo Akademi - Åbo Akademi University, 2015-01-23)
JNK1 is a MAP-kinase that has proven a significant player in the central nervous system. It regulates brain development and the maintenance of dendrites and axons. Several novel phosphorylation targets of JNK1 were identified ...