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Karaktärisering av humana NK-celler med specificitet mot immunoterapeutiskt (Fas 1) godkända NK-92-celler
(2021)
NK-celler har den unika kapaciteten att döda infekterade eller muterade celler snabbt och effektivt. Dessa egenskaper utnyttjades i denna pro gradu avhandling då cytotoxicitetsanalyser med varierande cytokiner utfördes. ...
Fosfataset alphabets roll i Drosophila melanogasters immunförsvar
(2021)
IMD-signalräckan hos bananflugan är en central immunsignaleringsräcka som aktiveras av gramnegativa bakterier. IMD-räckan behövs för att flugan ska inducera och utsöndra NF-κB-beroende antimikrobiella peptider, både vid ...
Modulation of Human Papilloma Virus transcription by Jagged1 in cervical cancer cell lines
(2021)
The Human Papilloma Virus (HPV) is a common sexually transmitted pathogen and the etiological agent for developing cervical cancer (CC). From the high-risk HPVs (hr-HPV), types 16 and 18 are the most prevalent ones. HPV ...
Comparison of in vitro high content screening methods for drug genotoxicity
(2021)
Detection of chemicals that induce damage to the DNA is an important aspect in drug development. The recognition of these chemicals is based on in vitro studies followed by in vivo studies, the latter being both expensive ...
Development of a T Cell Exhaustion Assay for Identification of Novel Immuno-Oncology Targets and In Vitro Drug Screening
(2021)
Cancer immunotherapy utilizes the body’s own immune system to treat cancer. The key cell type in immunotherapy is T cells. T cells recognize tumor-associated antigens through their T cell receptors (TCRs) and respond to ...
Engineering DoxA activity through the manipulation of associated electron transport partners
(2021)
Doxorubicin (DXR) is an anthracycline produced by some strains of the bacterium Streptomyces peucetius subsp. caesius. It is one of the most commonly used drugs in the treatment of several different types of cancer. It is ...
Autoimmunity-associated polymorphisms and their effects on the immunophenotype : Cohort generation and subject immunophenotyping in the Finnish Diabetes Prediction and Prevention study
(2021)
Type 1 diabetes (T1D) has a multifactorial etiology wherein both genetic and environmental factors predispose and modulate an individual’s risk of developing the disease. Hereditary factors are perceived to be the fundamental ...
Molekylära kopplingar mellan signalförmedlare i olika NF-κB-räckor i epitelceller i Drosophilas tarmkanal
(2021)
Bananflugan (Drosophila melanogaster) är en utmärkt modellorganism för att studera cell signaleringsräckor som reglerar aktiveringen av NF-κB-transkriptionsfaktorer. I Drosophila har två NF-κB-immunsignaleringsräckor ...
Developing an in vitro model and quantitation method for bone marrow adiposity research
(2021)
Bone marrow adipocytes (BMAds) have long been considered a passive and pathological filler within the bone marrow (BM) microenvironment. Recent studies suggest that BMAds may actively influence bone and energy metabolism. ...
Karakterisering av Notch1 fosforylering under replikationsstress
(2021)
Notch1 har en betydande roll i många av cellens funktioner. Tidigare studier visar att Notch deltar i regleringen av ATM/ATR-aktiveringen vid replikationsstress genom att binda till ATM, vilket inhiberar autofosforyleringen ...