Selaus nimekkeen mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 1-20 / 51
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3D structural modeling of Klebsiella pneumoniae SEFIR domain protein and insights into its putative interaction with IL-17 receptor A
(2022)Salassapidettävä 1.6.2026 asti -
Autoimmunity-associated polymorphisms and their effects on the immunophenotype : Cohort generation and subject immunophenotyping in the Finnish Diabetes Prediction and Prevention study
(2021)Type 1 diabetes (T1D) has a multifactorial etiology wherein both genetic and environmental factors predispose and modulate an individual’s risk of developing the disease. Hereditary factors are perceived to be the fundamental ... -
BET-hämmare för behandling av klarcellig äggstockscancer
(Åbo Akademi, 2019)Klarcellig äggstockscancer (eng. ovarian clear cell carcinoma, OCCC) är en ovanlig cancerform för vilken överlevnadsgraden är låg eftersom behandlingen inte har förbättrats på tiotals år. Sekvenseringsstudier har visat att ... -
Characterization of HSF1 Interactome during Anisomelic Acid Treatment Using TurboID Proximal Labeling
(2023)The heat shock response involves the expression of molecular chaperones that aid in re-folding or degradation of proteins in physiological and pathological conditions that promote accumulation of misfolded proteins. A key ...Embargo 16.6.2024 asti -
Comparison of in vitro high content screening methods for drug genotoxicity
(2021)Detection of chemicals that induce damage to the DNA is an important aspect in drug development. The recognition of these chemicals is based on in vitro studies followed by in vivo studies, the latter being both expensive ... -
—Danio rerio— : Extracellular matrix and cancer cell growth in the zebrafish xenograft model
(2023)Cancer is an exponentially growing health concern worldwide. Besides genetic mutations and altered proliferation patterns, the microenvironment, and the cancer cell niche function as an essential regulator of the tumors’ ... -
Deciphering the molecular composition of tricellular junctions
(Åbo Akademi, 2020)Tight Junctions (TJs) are intercellular adhesion complexes that contain an elaborate network of both transmembrane and cytosolic proteins, regulating epithelium integrity. In this thesis, I studied the interactome of a ... -
Developing an in vitro model and quantitation method for bone marrow adiposity research
(2021)Bone marrow adipocytes (BMAds) have long been considered a passive and pathological filler within the bone marrow (BM) microenvironment. Recent studies suggest that BMAds may actively influence bone and energy metabolism. ...Embargo 26.5.2022 asti -
Development of a T Cell Exhaustion Assay for Identification of Novel Immuno-Oncology Targets and In Vitro Drug Screening
(2021)Cancer immunotherapy utilizes the body’s own immune system to treat cancer. The key cell type in immunotherapy is T cells. T cells recognize tumor-associated antigens through their T cell receptors (TCRs) and respond to ...Salassapidettävä 27.5.2025 asti. -
drICE förhindrar bakterieförmedlad inflammation i Drosophila melanogasters tarm
(Åbo Akademi, 2018)Redan vid födseln koloniseras människans tarmkanal av symbiotiska bakterier, även kallade för kommensala bakterier. De kommensala bakteriearterna hjälper att skydda tarmepitelet från patogena mikroorganismer. En minskad ...Embargo 13.12.2021 asti -
dSting reglerar den antivirala NF-ĸB-förmedlade immunresponsen i bananflugan
(2022)Drosophila melanogaster (bananflugan) utgör en utmärkt modellorganism för studier inom immunförsvaret – närmare sagt det ospecifika immunförsvaret, då bananflugan saknar ett specifikt immunförsvar. Bananflugans immunresponser ... -
Effekten av DSS och mesoporösa kiseldioxidnanopartiklar på tarmfloran och inflammationsresponsen i Drosophila melanogaster
(Åbo Akademi, 2019)Drosophila melanogaster är en ofta använd modellorganism för att studera de bakomliggande genetiska och molekylära orsakerna till inflammatoriska tarmsjukdomar – sjukdomar som bl.a. karaktäriseras av en rubbad tarmflora, ...Embargo untill 11.6.2020 -
En ny roll för värmechockfaktor 2 i TGF-β-signalräckan
(Åbo Akademi, 2018)Embargo until 13.12.2023 -
Engineering DoxA activity through the manipulation of associated electron transport partners
(2021)Doxorubicin (DXR) is an anthracycline produced by some strains of the bacterium Streptomyces peucetius subsp. caesius. It is one of the most commonly used drugs in the treatment of several different types of cancer. It is ...Embargo 14/6/2022 asti. -
Epigenetic Markers in T-cell Acute Lymphoblastic Leukemia at Single-Cell Level
(Åbo Akademi, 2019) -
Etablering och karaktärisering av organotypiska 3D co-kulturer med tumör- och T-celler
(Åbo Akademi, 2018)Epitela tumörer bildas då normala celler omvandlas till tumörceller som börjar dela på sig okontrollerat till följd av genetiska eller externa faktorer. Till de vanligaste epitela cancertyperna hör prostatacancer (PrCa) ...Embargo until 18.1.2024 -
Evaluating tumour-specificity of mesoporous silica nanoparticle drug delivery in organotypic 3D cultures
(2022)Salassapidettävä 31/10/2026 asti. -
Folate receptor beta as an imaging target in myocardial infarction
(2023)For decades, myocardial infarction (MI) has been one of the leading causes of mortality worldwide. MI is characterized by different stages of inflammation of myocardium up to subsequent fibrosis. During the inflammatory ... -
Fosfataset alphabets roll i Drosophila melanogasters immunförsvar
(2021)IMD-signalräckan hos bananflugan är en central immunsignaleringsräcka som aktiveras av gramnegativa bakterier. IMD-räckan behövs för att flugan ska inducera och utsöndra NF-κB-beroende antimikrobiella peptider, både vid ...