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Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells : evidence for the involvement of HIF-I?, MMP2 and MMP9
(Åbo Akademi - Åbo Akademi University, 2015-09-11)
Sphingolipids are widely expressed molecules, which traditionally were considered to have majorly structural properties. Nowadays, however, they are implicated in a wide range of different biological processes. The bioactive ...
Networking Notch : regulation of Notch traffic and signaling crosstalk
(Åbo Akademi - Åbo Akademi University, 2015-10-13)
Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
(Åbo Akademi - Åbo Akademi University, 2014-08-29)
Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ...
Regulation of cell fate by c-FLIP phosphorylation
(Åbo Akademi - Åbo Akademi University, 2013-12-13)
Programmed cell death is an important physiological cellular process that maintains homeostasis and protects multicellular organisms from diseases. Apoptosis is the principal mode of cell death, which eliminates unwanted ...
The Role of Vimentin in Tissue Repair and Cell Growth
(Åbo Akademi - Åbo Akademi University, 2023-03-10)
Microfilaments, microtubules, and intermediate filaments serve as the cytoskeleton of the cell and form a complex network by interacting with cytoskeleton-associated proteins. The cytoskeleton provides a framework for the ...
HSF1 and HSF2 in Stress and EMT-Associated Transcriptional Networks
(Åbo Akademi - Åbo Akademi University, 2023-09-15)
Protein-damaging stress frequently occurs during the lifetime of a cell. To survive these insults, cells rely on the action of proteins called transcription factors that adjust the expression of genes, such as chaperones, ...
Calcium Signaling in Cell Compartments - the Importance of Sphingosine Kinase 1 and ORP5/8
(Åbo Akademi - Åbo Akademi University, 2023-06-21)
För att upprätthålla liv använder cellerna i en organism intrikata signaleringsräckor för regleringen av fysiologiska processer inom enskilda celler och mellan olika celler och vävnaderna som utgör en organism. Reglering ...
Intertwining Cell Adhesion, Gene Expression, and Stress
(Åbo Akademi - Åbo Akademi University, 2023-06-01)
Cells within an organism are constantly exposed to environmental insults that challenge the homeostasis of their proteome by causing protein misfolding. To survive these adverse situations, cells are equipped with a ...
Development of Novel Drugs Targeting Chaperones of Oncogenic K-Ras
(Åbo Akademi - Åbo Akademi University, 2021-02-12)
KRAS mutations account globally for about one million deaths per year, but there is as yet no approved drug against KRAS. K-Ras proteins are organized into di-/oligomeric nanoscale signaling complexes, known as nanoclusters ...
Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
(Åbo Akademi - Åbo Akademi University, 2016-04-29)
The signalling sphingolipid sphingosine-1-phosphate (S1P) is necessary for development of the immune system and vasculature and on a cellular level regulates migration, proliferation and survival. Due to these traits S1P ...