Viitteet 1-10 / 20
Regulation of Notch Signaling by Intracellular Trafficking
(Åbo Akademi - Åbo Akademi University, 2020-02-21)
The Notch signaling pathway is one of the essential mediators of cell-cell communication during development of multicellular organisms. Notch signaling is based on receptors and ligands that interact between neighboring ...
The Role of Vimentin in Tissue Repair and Cell Growth
(Åbo Akademi - Åbo Akademi University, 2023-03-10)
Microfilaments, microtubules, and intermediate filaments serve as the cytoskeleton of the cell and form a complex network by interacting with cytoskeleton-associated proteins. The cytoskeleton provides a framework for the ...
HSF1 and HSF2 in Stress and EMT-Associated Transcriptional Networks
(Åbo Akademi - Åbo Akademi University, 2023-09-15)
Protein-damaging stress frequently occurs during the lifetime of a cell. To survive these insults, cells rely on the action of proteins called transcription factors that adjust the expression of genes, such as chaperones, ...
Calcium Signaling in Cell Compartments - the Importance of Sphingosine Kinase 1 and ORP5/8
(Åbo Akademi - Åbo Akademi University, 2023-06-21)
För att upprätthålla liv använder cellerna i en organism intrikata signaleringsräckor för regleringen av fysiologiska processer inom enskilda celler och mellan olika celler och vävnaderna som utgör en organism. Reglering ...
Intertwining Cell Adhesion, Gene Expression, and Stress
(Åbo Akademi - Åbo Akademi University, 2023-06-01)
Cells within an organism are constantly exposed to environmental insults that challenge the homeostasis of their proteome by causing protein misfolding. To survive these adverse situations, cells are equipped with a ...
Identification of Three Conserved Interaction Zones Around the Catalytic Machinery of alpha/beta- Hydrolase Fold Enzymes
(Åbo Akademi - Åbo Akademi University, 2020-03-06)
The alpha/beta-Hydrolases (ABH) comprise one of the largest structural families of proteins, found in all organisms. Although they share low sequence similarity, the ABH fold enzymes maintain a common catalytic domain, the ...
Development of Novel Drugs Targeting Chaperones of Oncogenic K-Ras
(Åbo Akademi - Åbo Akademi University, 2021-02-12)
KRAS mutations account globally for about one million deaths per year, but there is as yet no approved drug against KRAS. K-Ras proteins are organized into di-/oligomeric nanoscale signaling complexes, known as nanoclusters ...
Vimentin links hemodynamic forces and Notch signaling in vascular tissue remodeling
(Åbo Akademi University, 2021-07-09)
Mechanisms of Nascent Transcription in Cell Stress
(Åbo Akademi - Åbo Akademi University, 2022-05-13)
Cells are constantly exposed to various types of stress, such as proteotoxic stress, oxidative stress, and hypoxia. Survival under these circumstances requires genome-wide reprogramming of transcription involving both ...
Specificity Determining Features at the Interface of Biomolecular Complexes as Regulators of Biological Functions
(Åbo Akademi - Åbo Akademi University, 2023-01-13)
Amino acid residues at the biomolecular interface play essential roles in many biological and cellular processes; relevant to this thesis, protein-protein interactions regulate signaling pathways and enzymatic activity, ...