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Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells : evidence for the involvement of HIF-I?, MMP2 and MMP9
(Åbo Akademi - Åbo Akademi University, 2015-09-11)
Sphingolipids are widely expressed molecules, which traditionally were considered to have majorly structural properties. Nowadays, however, they are implicated in a wide range of different biological processes. The bioactive ...
Networking Notch : regulation of Notch traffic and signaling crosstalk
(Åbo Akademi - Åbo Akademi University, 2015-10-13)
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Membrane properties of structurally modified ceramides : effects on lipid lateral distribution and sphingomyelin-interactions in artificial bilayer membranes
(Åbo Akademi - Åbo Akademi University, 2014-03-14)
Ceramides comprise a class of sphingolipids that exist only in small amounts
in cellular membranes, but which have been associated with important roles in
cellular signaling processes. The influences that ceramides have ...
Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
(Åbo Akademi - Åbo Akademi University, 2014-08-29)
Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ...
Regulation of cell fate by c-FLIP phosphorylation
(Åbo Akademi - Åbo Akademi University, 2013-12-13)
Programmed cell death is an important physiological cellular process that maintains homeostasis and protects multicellular organisms from diseases. Apoptosis is the principal mode of cell death, which eliminates unwanted ...
Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
(Åbo Akademi - Åbo Akademi University, 2016-04-29)
The signalling sphingolipid sphingosine-1-phosphate (S1P) is necessary for development of the immune system and vasculature and on a cellular level regulates migration, proliferation and survival. Due to these traits S1P ...
Phosphorylation as a mediator of protein function in cell migration, differentiation, and death : vimentin, AATF, and Par-4 in the spotlight
(Åbo Akademi - Åbo Akademi University, 2016-11-11)
Protein phosphorylation is a major regulator of cellular signaling. It functions when a kinase joins a phosphate group to a protein, or when a phosphatase strips off a phosphate group from serine, threonine, or tyrosine ...
Stress management : multilayer regulation of the heat shock response
(Åbo Akademi - Åbo Akademi University, 2017-04-21)
Protein-damaging stresses, such as exposure to elevated temperature, alcohol, and heavy metals and microbial infections, increase the amount of misfolded proteins in cells, which may lead to formation of toxic protein ...
Structure in stress management : Keratins in intestinal stress protection
(Åbo Akademi - Åbo Akademi University, 2016-12-16)
Intermediate filaments (IFs), a major constituent of the cellular cytoskeleton, contribute mainly to the mechanical stability of the cell. Simple epithelial keratins (SEKs) are IF proteins expressed in the single-layered ...
On the Evolution, Function and Pathogenesis of Intermediate Filaments
(Åbo Akademi - Åbo Akademi University, 2017-06-02)
Intermediärfilament (IF) är nukleära och cytoplasmiska strukturprotein. I människans genom ingår 70 gener som kodar för 74 hittills kända intermediärfilament. Mutationer i dessa gener orsakar många allvarliga sjukdomar. ...