Preparation and characterization of polymer carrier matrices for printed wound dressings
Rönkönharju, Sophie (2018)
Rönkönharju, Sophie
2018
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi-fe202301021107
https://urn.fi/URN:NBN:fi-fe202301021107
Tiivistelmä
There is a vast variety of wounds that demand different therapeutic approaches for healing. Reports on real-world evidence have shown that there is a constant need for better wound dressings, as both the number of acute and chronic wounds are increasing yearly. The modern wound dressings must meet certain criteria for enhancing the wound healing process. Wound dressings often utilize bioactive compounds such as chitosan, elastin, alginate or collagen in combination with synthetic polymers for better mechanical properties. Furthermore, different methods, such as inkjet printing, can be applied to incorporate active pharmaceutical ingredients into the wound dressings. Modern wound dressings are aimed to actively promote the healing process and provide mechanical and thermal protection for the wound, in addition to the low cost and inconvenience for the patient. Since the shape of the body parts varies extensively, it is preferable to have flexible wound dressings that are easily applied with a non-adhesive surface towards the wound. The challenge lies in finding a formulation that would be able to absorb excess fluids of the wound but retain a moist environment and promote rapid healing without having to be removed often. These requirements put high demands on the swelling ability, mechanical properties and physicochemical stability of the materials used in the wound dressings.
In this study, a bioactive compound sodium alginate was used in combination with the synthetic polymer polyvinyl alcohol to prepare wound dressing substrates by electrospinning, solvent casting, three-dimensional printing technology and the combination of them. The primary goal was to investigate the physicochemical properties and the stability of the prepared single and bi-layered substrates. Furthermore, their suitability as carrier substrates for inkjet printing of active compounds was evaluated.
Thermal crosslinking method was applied to the substrates to improve their stability in aqueous environment. Infrared spectroscopy and differential scanning calorimetry showed that the solvent cast films resulted in the most stable substrate after a storage period of one month. Additionally, the mechanical properties of all substrates were not affected by the bilayered structure nor the crosslinking of the substrates. The substrate-ink interactions of all substrates were investigated for the incorporation of active compounds by inkjet printing. The crosslinked nanofibres exhibited low adhesion to artificial skin membrane and they seemed to be highly suitable for further functionalization by inkjet printing. Thus, this type of wound dressing substrates with a porous surface have a high potential to be used in wound care in the future.
In this study, a bioactive compound sodium alginate was used in combination with the synthetic polymer polyvinyl alcohol to prepare wound dressing substrates by electrospinning, solvent casting, three-dimensional printing technology and the combination of them. The primary goal was to investigate the physicochemical properties and the stability of the prepared single and bi-layered substrates. Furthermore, their suitability as carrier substrates for inkjet printing of active compounds was evaluated.
Thermal crosslinking method was applied to the substrates to improve their stability in aqueous environment. Infrared spectroscopy and differential scanning calorimetry showed that the solvent cast films resulted in the most stable substrate after a storage period of one month. Additionally, the mechanical properties of all substrates were not affected by the bilayered structure nor the crosslinking of the substrates. The substrate-ink interactions of all substrates were investigated for the incorporation of active compounds by inkjet printing. The crosslinked nanofibres exhibited low adhesion to artificial skin membrane and they seemed to be highly suitable for further functionalization by inkjet printing. Thus, this type of wound dressing substrates with a porous surface have a high potential to be used in wound care in the future.
Kokoelmat
- 317 Farmasia [19]